The Deming Lab
University of California, Los Angeles
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Polypeptide Synthesis
NCA Monomer Preparation and Polymerization
The building blocks of synthetic polypeptides. N-carboxyanhydrides (NCAs) can often be prepared in large scale (grams to kilograms) in a single step from amino acids.
Cheng, J.; Deming, T. J. Top. Curr. Chem., 2012, 310, 1-26.
Polypeptide Synthesis via Catalysis
Our catalysis chemistry allows allows living polymerization of NCAs with significant rate enhancement over conventional initiators.
Deming, T. J.; Curtin, S. A. J. Am. Chem. Soc., 2000, 122, 5710-5717.
Curtin, S. A. and Deming, T. J. J. Am. Chem. Soc., 1999, 121, 7427-7428.
Deming, T. J. Macromolecules, 1999, 32, 4500-4502.
Deming, T. J. J. Am. Chem. Soc., 1998, 120, 4240-4241.
Deming, T. J. Nature, 1997, 390, 386-389.
